Conclusions Improvements in the Interobserver Agreement in the classification of adenoma architecture suggest that national guidelines may be useful for the dissemination of knowledge, but variability in the diagnosis of LGDs, even after a revision of the guidelines, suggests that ongoing knowledge transfer exercises are needed. To the editor: We read with great interest the work of Lugli et al. [1] on the fascinating theme of tumor germ (to), an independent and robust prognostic factor in colon cancer, but without a standardized method for its evaluation until consensus in 2016. However, there is no information on the variability of Interobserver that uses consensus, and we have some concerns. Kato S, Fujii T, Koba I, Sano Y, Fu KI, Parra-Blanco A, Tajiri H, Yoshida S, Rembacken B (2001) Assessment of colorectal lesions by magnifying glass and mucous dye: Can significant lesions be distinguished? Endoscopy 33:306-310 Although the reproducibility of the pit pattern interobservator is good for experienced endoscopists, MC should not be used to replace histopathological analysis, as it does not distinguish with the necessary safety neuroplasty from non-neoplastic lesions. We evaluated the agreement among observers on the number of buds and the degree of tuberculosis in 50 successive colon cancer samples, applying the consensus criteria, and found some interesting results. TB was achieved by a ×20 lens lens with a 20mm eye count in one turn and in a ×20 lens lens with a 22mm eye lens in another lens; the latter method required the application of the formula proposed by Lugli et al., resulting in a decimal number. The evaluation was conducted blindly by two experienced gastrointestinal pathologists and two pathology residents to assess the agreement between the observers () and the method of determining the number of buds (because one method gives a decimal number and the other method an entire number) to determine whether the degree of tuber could be altered. The general census agreement for the exact number of buds was 52% (-0.28). Comparing the results of decimals, the number of TB was rounded or lowered (based on the figure closest to 0.5) and the agreement was 50% (-0.25).

In no way did the rounding of the number affect the degree of TB. The general correspondence among pathological experts was 54% (up 0.3) and 48% for the inhabitants (up 0.2). The overall approval rate of the TB class for the application of the consensus was 97.3% (up 0.96), with 100% of the support of the experts. Methods and results: Twelve benign polyps, representative of bcs cases, were identified from pathology files and were reported by 28 BCS histopathologists with proform sheets.